(ANKARA and LONDON) -- President Donald Trump said on Wednesday morning that he believes that the interim agreement reached with Iran last month is "over," following an intense exchange of fire between the two sides on Tuesday into Wednesday morning.

Trump huddled with top advisers on Tuesday while attending the NATO summit in Ankara, Turkey, to discuss the U.S. response to several fresh attacks on commercial ships in the Strait of Hormuz early this week, multiple people familiar with the discussions told ABC News.

The U.S., Qatar and Saudi Arabia attributed the attacks to Iranian forces, allegations denied by Tehran.

Speaking with reporters in Ankara on Wednesday during a press conference alongside NATO Secretary General Mark Rutte, Trump said that negotiations between the U.S. and Iran will continue, but said of the agreement, "For me, I think it's over."

"I don't want to deal with them anymore. They're scum. You know what scum is? They're scum. They're sick people. They're led by sick people," Trump said of Iran's leadership in response to a question from ABC News.

"And they're vicious, violent people. And if they had a nuclear weapon, they'd use it. As far as I'm concerned, it's over," the president continued. "There's something wrong with them, they're cuckoo," Trump added.

The president did, however, suggest that U.S.-Iranian negotiations over a final peace deal could continue.

The 14-point MOU committed the signatories to the reopening Strait of Hormuz for commercial traffic, with the U.S. lifting its naval blockade of Iranian ports. Iran also committed not to pursue nuclear weapons -- a commitment Tehran has previously made -- while the U.S. agreed to allow Iranian oil sales and to begin work on a $300 million reconstruction fund for the country.

Under the MOU, fighting -- including between Israel and the Tehran-backed Hezbollah militia in Lebanon -- would stop for 60 days while the U.S. and Iran negotiate the terms of a final deal, which would cover issues including Iran's nuclear material.

"I'll speak to our negotiators. They want to negotiate. They're good people. Steve Witkoff, Jared Kushner, but they have to come back to me. As far as I'm concerned, it's just a waste of time dealing with them," Trump said on Wednesday.

"I'll let our wonderful negotiators keep talking if they want, but I don't see it," Trump said later in the press conference, adding that he did not care whether talks continued after funeral proceedings for slain Supreme Leader Ayatollah Ali Khamenei concluded.

When the MOU was signed last month, Trump said the deal "achieves everything we set out to accomplish, everything and much more." But key issues, including the status of Iran's nuclear program, remained unaddressed.

The White House has demanded an end to all Iranian enrichment of uranium, a proposal repeatedly rebuffed by Tehran, which says it needs to enrich uranium to power its civil nuclear power network.

On Wednesday, the president again said his administration would accomplish the "denuclearization of Iran."

"We're going to de-nuke it. We're not going to let them, because they're crazy, and they can't have a nuclear weapon," Trump said.

Intermittent exchanges of fire have continued between the U.S. and Iran despite the signing of the MOU in June.

Since Monday, U.S. Central Command said Iran had attacked three commercial vessels transiting the Strait of Hormuz.

CENTCOM said it then launched retaliatory strikes on more than 80 Iranian targets, including air defense systems, command and control networks, coastal radar sites, anti-ship missile capabilities and small boats.

The U.S. also revoked a license that authorized the sale of Iran oil under the MOU in response to the tanker attacks, with one U.S. official telling ABC News that the incidents were "wholly unacceptable."

Iran's military said on Wednesday that it responded to the renewed American strikes by attacking 85 U.S. military sites in Kuwait and Bahrain.

Trump on Wednesday lauded what he called the "powerful" U.S. strikes, adding, "We hit them very hard."

"I told them every time you hit, we hit, and of course they're dirty players, so they go after everyone, probably including me," the president continued, referring to alleged Iranian assassination plots in which Trump said he remains a target.

"They want to take out the U.S. leader -- me. I'm on every list. I saw things this morning, I'm on every single one of their lists, and so far I guess I've been a little bit lucky, but that maybe doesn't last very long, because that's the way it goes," Trump said.

Mohammad Bagher Ghalibaf, the speaker of the Iranian parliament who has been serving as Tehran's chief peace negotiator, said in a post to X early on Wednesday that the U.S. had violated the MOU with its latest strikes.

"The era of bullying and extortion is over. It leads nowhere. We don't fold," Ghalibaf wrote.

Oil prices spiked on Wednesday after Trump's comments, with U.S. oil trading at $74.62, up around 6%, and global oil at $78.70, up more than 6%. The price of global oil is still significantly down on a high of nearly $120 last month before the MOU was announced.

Traffic has been moving through the Strait of Hormuz in recent weeks, including through Tuesday despite the latest attacks on ships. Data from Kpler, a global energy analytics firm, showed more than 100 transits of ships through the Strait between July 5 and July 7, including 41 crossings on July 7.

ABC News' Rachel Scott, Karen Travers, Justine Fishel, Isabelle Murray, Sarah Kolinovsky and Zunaira Zaki contributed to this report.

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